Isao SHIMIZU, Professor

(Synthetic Organic Chemistry)

B.S. (1975, Tokyo Inst. Tech), Ph.D. (1980, Tokyo Inst. Tech), Res. Assoc. (1980, Tokyo Inst. Tech), Assist. Prof. (1985, Waseda), Assoc. Prof. (1987, Waseda), Professor (1992, Waseda).
Award for Young Chemists: The Chemical Society of Japan (1986).


Biologically Active Substances / Synthetic Design / Molecular Catalysis / Organometallic Chemistry / Asymmetric Synthesis

Tel: +81-3-5286-3205

Fax: +81-3-3232-5270

Research Interests

Recent research in this laboratory has centered on the development of useful organic synthetic methodology based on catalytic reactions utilizing transition metal complexes. Synthetic strategies for biologically active substances such as steroids, terpenoides, alkaloids, antibiotics, and insect pheromone as enatiomeric pure forms have also been developed.

Representative Publications

1."Enantioselective Nucleophilic Substitution of a 6,6-Bicyclic Dienyl Acetate by Palladium-Chiral Phosphine Catalyst", Chem. Lett., 1998, 983-984.

2."A Short Enantioelective Synthesis of a Component of Cryptophycin A and Arenastatn A", Tetrahedron Asym., 9, 1351-1357 (1998).

3."Synthesis of Triangular and Tetrahedral Hetronuclear Metal Clusters Using Hydride Complexes of Cyclopentadienyl-rhodium and Ruthenium as the Presursors", Organometallics, 17, 262-269 (1998).

4."Molybdenum- and Tungsten-Catalyzed Allylation of Aromatic Compounds with Allylic Esters and Alcohols", Chem. Lett., 1997, 137-138.

5."Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing and a,b-Unsaturated Ester Group", Tetrahedron, 53, 12933-12946 (1997).

6."Molybdenum-Catalyzed Aromatic Substitution with Olefins and Alcohols", Chem. Lett., 1997, 851.

7."Removal of a Palladium-Bound Tertiary Phosphine Ligand with Silver (I) Salts to Generate Cationic Monoorgano-palladium (II) Complexes Having One Trimethylphosphine Ligand", Bull. Chem. Soc. Jpn., 70, 1135-1140 (1997).

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